cy cat hy 17420 Search Results


cyclophosphamide  (MedChemExpress)
94
MedChemExpress cyclophosphamide
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Cyclophosphamide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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neratinib  (MedChemExpress)
92
MedChemExpress neratinib
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Neratinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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capecitabine  (MedChemExpress)
93
MedChemExpress capecitabine
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Capecitabine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pyrotinib dimaleate  (MedChemExpress)
93
MedChemExpress pyrotinib dimaleate
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Pyrotinib Dimaleate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lapatinib  (MedChemExpress)
94
MedChemExpress lapatinib
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Lapatinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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carboplatin  (MedChemExpress)
95
MedChemExpress carboplatin
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Carboplatin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pembrolizumab [keytruda  (Merck & Co)
90
Merck & Co pembrolizumab [keytruda
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Pembrolizumab [Keytruda, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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protease inhibitor cocktail  (Sangon Biotech)
90
Sangon Biotech protease inhibitor cocktail
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Protease Inhibitor Cocktail, supplied by Sangon Biotech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cy cat hy 17420  (MedChemExpress)
93
MedChemExpress cy cat hy 17420
Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, <t>cyclophosphamide;</t> RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.
Cy Cat Hy 17420, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, cyclophosphamide; RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.

Journal: Experimental and Therapeutic Medicine

Article Title: Circular RNA expression profiling and the potential role of hsa_circ_0005379 in decreased ovarian reserve

doi: 10.3892/etm.2025.12974

Figure Lengend Snippet: Function of hsa_circ_0005379 in CTX-induced KGN ovarian granulosa cells. (A) Different gradient concentrations (0, 10, 15, 20, 25 and 30 µM) of CTX were used to induce ovarian granulosa cell damage, and Cell Counting Kit-8 assay was used to detect KGN cell viability. (B) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with three shRNAs and negative control sh-NC. (C) RT-qPCR analysis of hsa_circ_0005379 expression after transfection with OE vector and an empty OE-NC vector. (D) The apoptosis of sh-hsa_circ_0005379 or hsa_circ_0005379-OE transfected KGN cells was detected using annexin V/PI staining. (E) Flow cytometry was used to detect the ROS level of cells after different treatments. The concentration of (F) MDA and (G) SOD in KGN cells with different treatments was determined using corresponding biochemistry detection kits. n=3, * P<0.05, ** P<0.01 and *** P<0.001 vs. 0 µΜ or as indicated. CTX, cyclophosphamide; RT-qPCR, reverse transcription-quantitative PCR; OE, overexpression; NC, negative control; sh, short hairpin; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; MFI, mean fluorescence intensity; ns, not significant.

Article Snippet: Cyclophosphamide (CTX; cat. no. HY-17420; MedChemExpress) may destroy the follicular pool, leading to primary ovarian insufficiency ( ).

Techniques: Cell Counting, Quantitative RT-PCR, Expressing, Transfection, Negative Control, Plasmid Preparation, Staining, Flow Cytometry, Concentration Assay, Reverse Transcription, Real-time Polymerase Chain Reaction, Over Expression, Fluorescence